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In this study, phosphotoxic protein inhibited melanin synthesis by downregulating the expression of MITF, TRP-1, TRP-2, and tyrosinase in B16F10 cells and reducing cAMP levels (Jung et al., 2012)

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Proteases in the peritoneal fluid appear to degrade GLP-1 faster than normal, creating a pro-inflammatory environment where the natural braking mechanisms on inflammation are weakened

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